Microplates FAQ

What are edge effects?

 A:  The “edge effect” is a discrepancy between the inner and outer wells (local environment), where each well has it’s own unique environment. Edge effects are commonly seen in high density formats as well volumes decrease as density increases.

Environmental edge effects can lead to variation across microplates, compromising the efficacy, reproducibility and reliability of cell-based assays. Fluctuations in environmental conditions, such as temperature and CO2 concentration, can trigger a variety of unwanted cellular responses and result in the evaporation of culture medium from the perimeter wells. Consequently, the micro-environment of the outer wells varies considerably from that of the inner ones, altering cell viability and assays results

What is the surface area of the BioClime™+ 96 Gel Microplate wells?

BioClime™+ 96 Gel microplates have a reduced surface area (half), compared to many other commercially available 96 well microplates, facilitating the use of lower reagent volumes while at the same time supporting a broad working volume of 10 – 150uL. This feature, combined with reduced evaporation due to environmental buffering, means significant savings as regards media, reagents, and valuable biological material.

What is the surface area of BioClime™ 96 Microplates wells?

BioClime™ 96 Microplates have a reduced surface area (half), compared to many other commercially available 96 well microplates, facilitating the use of lower reagent volumes while at the same time supporting a broad working volume of 10 – 150uL. This feature, combined with reduced evaporation when the inter-well spaces are filled water with results in significant savings as you use less media, reagents and valuable biological material.

Are BioClime™ 96 Microplates and BioClime™ + 96 Gel Microplates compatible with imaging instruments such as confocal microscopes and high content analysers?

BioClime™ 96 Microplats and BioClime™ + 96 Gel Microplates are made from imaging grade materials. They also possess flat well bottoms to facilitate imaging up to 40x magnification.

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